| （英） |
The effect of music on brain activity is often the focus of medical attention, but the mechanism remains unclear. In this study, we used rats as experimental models to investigate their motor and neural activity in response to music. We used Mozart's "Sonata for Two Pianos in D Major, K. 448 (375a)". We found that rats showed the most pronounced beat synchronization in the original piece, that they did not show beat synchronization at faster tempos, and that changes in beat synchronization in music were similar in rats and humans. Furthermore, the auditory cortex of rats showed the most pronounced beat synchronization in the original piece (132 BPM). We also examined the activity of the auditory cortex in response to simple rhythmic sound stimuli and found that the clearest beat synchronization occurred around 120 BPM. We considered the adaptation characteristics of the brain as a mechanism for generating synchronization at 120 BPM, created a mathematical model of it, and used it to explain the experimental data. The adaptation characteristics estimated from the rat brain not only generated synchronization around 120 BPM, but also showed the possible relationship to the appreciation and creation of music. These results suggest that the brain dynamics that produce beat synchronization have been inherited from the rodent brain to the human brain. Thus, music has evolved over many years in human society, and thereby has the potential to exert a strong attraction on the brain across animal species. Given the dynamics of the brain, we believe that music can be used in medicine as a tool to regulate neural activity. |